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Similarly, in a multicenter phase II study with dose adjustment according to baseline serum bilirubin level, the antitumor activity of single agent irinotecan was not significant in advanced HCC, although it exhibited a favorable toxicity profile [222]

Biochim Biophys Acta 1981, 677: 7-12

Angajala A, Lim S, Phillips JB, Kim J-H, Yates C, You Z, Tan M (2018) Diverse roles of mitochondria in immune responses: novel insights into immuno-metabolism