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Native peptide drugs, however, are generally ineffective when given orally due to low oral bioavailability, which is as a result of the physical and biochemical barriers of the gastrointestinal tract (GIT), often forcing the use of invasive parental delivery methods that lead to low patient compliance [3,4]

Understanding these mechanisms helps explain why deficiency produces such varied neurological manifestations and why early treatment is critical

Steroids directly influence androgen receptors, while many peptides studied for muscle growth affect growth hormone or recovery pathways

Peptide therapies should only be initiated under the care of a licensed medical provider following an appropriate evaluation