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Specifically, in the 1st week, there was an infiltration of inflammatory cells, whereas the controls presented prominent edema, with no proliferation of collagen fibers (Figure 19)

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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition