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Trends Pharmacol Sci (2018) 39(5):51324

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Unlike small molecule drugs requiring hepatic cytochrome P450 metabolism, PT-141s peptide structure results in: Breakdown into constituent amino acids through peptidase activity No significant cytochrome P450 enzyme interactions Minimal potential for drug-drug interactions through metabolic pathways No active metabolites requiring consideration for efficacy or safety The peptides metabolic profile contributes to its favorable safety regarding drug interactions, with no clinically significant interactions identified with alcohol or common medications

7 Investigation of GPX4 degradation mechanism after treatment with ferroptosis inducers