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Effects of selected approved AOMs on physiological systems and conditions Effects on joints Osteoarthritis (OA) is a degenerative joint disease closely associated with obesity, as excess body weight increases the mechanical stress on joints and exacerbates systemic inflammation

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Nlel-AnglV and Dihexa increase miniature synaptic activity by increasing dendritic spine densities and altering the morphological phenotype of postsynaptic spines in- vitro and may represent the mechanism that underlies facilitated learning observed AnglV analogues