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Tackling the problems of tumour chemotherapy by optimal drug scheduling

USA 102 , 30163021 (2005)

3 Avoids pituitary suppression: By avoiding supraphysiologic levels and inducing episodic pulses within a circadian rhythm context, sermorelin causes minimal pituitary suppression or tachyphylaxis, and does not perturb adjacent hormonal feedback loops

It was discovered by sequencing the follicular GCs of OEM patients and normal female follicular GCs that the differently expressed genes were primarily abundant in the MAPK, Protein WNT(WNT) signaling pathway, apoptosis, and steroid hormone response (54)