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The novel mitochondrial inhibitor IACS-010759 (OPi) suppresses mTOR by enhancing the activity of the AMPK pathway and inhibiting OXPHOS

HPLC analysis of the crude reaction mixture of reagent 1 (1 equiv) with PC8 (0.9 equiv) in ACN:PB (50 mM, pH 7, v/v = 2:3) shows high conversion to the corresponding 1,6-conjugate 11 after 4 h along with the remaining excess of starting material 1 (Fig

The properties of pyridazinediones, how they are constructed and how they have been applied in various fields of organic synthesis, medicinal chemistry and chemical biology will be highlighted