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For kinetics analysis of Cp1D and Cp2D for the amidation, a similar procedure to that mentioned above was used except for various concentrations of a single diastereomer (2 S ,3 S )- t -ES-Ile or (2 R ,3 R )- t -ES-Ile

doi: 10.1038/s41419-023-05629-y 360 SmedlundKBSanchezERHindsTJ

Together, these strategies demonstrate the therapeutic potential of targeting cancer cell metabolism in the context of hypoxia, particularly when combined with immunotherapy or standard chemoradiation

Transgenic mice carrying the erythropoietin gene promoter linked to lacZ express the reporter in proximal convoluted tubule cells after hypoxia