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Reported Adverse Effects From the limited human studies and anecdotal reports from users, the following side effects have been documented: Injection site pain and local reactions Joint pain or exacerbation of existing joint discomfort Anxiety and mood disturbances Palpitations and cardiovascular symptoms Insomnia or sleep disruption Nausea and gastrointestinal discomfort The frequency and severity of these effects remain unclear because no systematic adverse effect monitoring has been conducted across a large human population

& Weller, M

Moreover, sleep scoring was performed by different experts at the respective sleep centers, potentially introducing inter-rater bias

The two-tailed unpaired t-tests were used for single comparisons, and the analysis of variance (ANOVA) with Tukeys multiple comparison test was used for multiple comparisons