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DNA extraction Total DNA was isolated from approximately 250350 mg of homogenized fecal samples using the QIAamp Fast DNA Stool Mini Kit (Qiagen, Hilden, Germany) as per manufacturers instructions, with the following modifications

For AC vs non-AC, there was variability over time in bluetooth sensors (a proxy for social interaction, number of messages sent and received, and app usage (see Figure 1, panel B )

The relative risk of polyneuropathy (relative risk: 1), however, was comparable between the two groups

SLC25A15 has been identified as a tumor suppressor in HCC, and its deficiency leads to reprogramming of glutamine metabolism, which promotes cancer cell development [16]