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[DOI] [PubMed] [Google Scholar] 164.Polimeni M et al

Free radical-mediated damages of lipids, proteins, and nucleic acids are seen during enhanced OS

found that the expression of Prdx6 was regulated by specificity protein 1 (Sp1) at the transcriptional level, and the upregulation of Prdx6 could prevent podocyte impairment in DKD by alleviating oxidative stress and ferroptosis[84]

Thus, both HPX surface binding and endocytosis are significantly decreased by holo-Tf pre-incubation, strongly supporting that TfRs are involved in HPX endocytosis