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An estimated 3-12% of people treated with opioids for chronic pain will develop an addiction or abuse with negative consequences.(12) Approximately 8.6 million Americans reported misusing prescription opioids in 2023.(13) People who develop tolerance or dependence to prescription opioids may transition to illegally produced opioids, such as a fentanyl

EsfandiariAPourghassem GargariBNoshadHSarbakhshPMobasseriMBarzegariMet al

Many substances being discussed have enthusiastic supporters as well as critics who point to limited human clinical data