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Beyond its association with vascular risk and cognitive decline (which we cover in our B12 for memory and brain health guide), elevated homocysteine has been linked to neuroinflammation and oxidative stress in brain tissue both of which are implicated in mood disorders

However, hemodynamic abnormalities, such as those caused by hypertension or extreme stress, can lead to extracellular matrix injury and the rupture of the basement membrane

Extra fat tissue produces more estrogen, which can disrupt the balance between estrogen and progesterone (14)

Again, that's functionhealth.com/huberman to get early access to Function