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PdxCre mice) and orthotopic transplantation of KPC derived cells, MET inhibition with capmatinib sensitised PDAC tumours to gemcitabine, resulting in a reduction in primary tumour volume and metastatic burden via increased apoptosis [57]

These are reasonable interventions for appropriate candidates, with genuine uncertainty about how well any individual result generalizes

This observation is particularly important because it demonstrates that these drugs can remain effective even in the absence of the MC4R pathway, which is traditionally thought to play a key role in regulating energy balance and appetite