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By loading anti-inflammatory and tissue-repair molecules onto the acupuncture, these approaches achieved synergistic therapy where the needle delivers the drug upon insertion, establishing a new paradigm for localised, precise drug administration in KOA ( The cited studies collectively demonstrate the technical feasibility and precision-targeting capability of OFA as a platform for deep-tissue energy delivery, which forms a foundational rationale for its application in intra-articular PBM for KOA

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