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Furthermore, although LOLA initially lowers blood ammonia levels, even in end-stage liver disease, its effects appear to be temporary as a rebound hyperammonemia is sometimes observed on cessation of the drug [72]

Nat Med 24:15791589 Rothstein JD, Caroline Warlick ANC (2023) Highly variable molecular signatures of TDP-43 loss of function are associated with nuclear pore complex injury in a population study of sporadic ALS patient iPSNs