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2019;364:k5224

While the large majority of previous research into the G3BPs has centered on stress granules 41,42,43 , multiple studies have demonstrated that these proteins exert a diverse array of cellular-context-dependent functions, including in tethering the TSC complex to lysosomes 10 , functioning as an ATP- and magnesium-dependent helicase 12 , and promoting CGAS/STING signaling 44 , among others 45

Moreover, schistosome TGR mRNA is alternatively spliced, producing both cytoplasmic and mitochondrial forms of the enzyme (LLC and DLW, unpublished data)

The data on DSIP come from basic research they do not confirm efficacy or safety in humans