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This copper-chaperoning function contributes to GHK-Cu's observed effects on antioxidant defense and tissue structural integrity in research models

Recently, several studies have demonstrated that patients with PD have gut dysbacteriosis and emphasize the effect of the gut microbiota on the braingut axis [35, 36]

specifically in those lines with elevated OAS levels ( Figure 7A )

In addition, mTORC1 promotes nucleotide synthesis by stimulating the mTHF cycle, which increases ATF4 levels to upregulate the expression of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) [45]

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