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The process of Gln entering the cytoplasm is primarily facilitated by a specific solute carrier, designated as ASCT2

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Other fields exploring intranasal drug delivery include epilepsy, brain tumors and multiple sclerosis

In our study, RNA-seq of RTECs with REST knockdown under HR, primary RTECs of mice with Rest knockout, histological examination of Rest RTKO mouse kidneys, and TEM observations collectively demonstrated that ferroptosis was one of the key regulatory pathways through which REST contributed to AKI-to-CKD transition