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It can lead to a condition called kernicterus, a rare type of brain damage that can be fatal

Chromatin gets subject to a drastic remodelling throughout which almost all of (9095 %) of the H2A , H2B , H3 and H4 (nucleosomal core histones) are replaced by transitional proteins first and by protamines afterwards (Reference McSwiggin and O'Doherty19)