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NR = not reached At the protocol specified final OS analysis, the median in the pemetrexed in combination with pembrolizumab and platinum chemotherapy arm was 22.0 months (95% CI: 19.5, 24.5) compared to 10.6 months (95% CI: 8.7, 13.6) in the placebo with pemetrexed and platinum chemotherapy arm, with an HR of 0.56 (95% CI: 0.46, 0.69)

doi: 10.1053/jhep.2001.23505

4,7-9 About one-third of patients will present with nonspecific symptoms (e.g., fever, headache, sore throat, cough, malaise) and/or burning of the eyes followed by the appearance of mucocutaneous lesions of the eyes, mouth, genitals, and urinary tract in 1 to 3 days

No washout period or dose adjustment is needed