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As a lyophilized powder, AHK-Cu is generally reported in the literature as stable under proper storage, with the copper-peptide complex conferring a degree of oxidative resistance relative to uncomplexed peptide chains

Cyanocobalamin is the most common form used in pharmaceutical preparations

Because people who have difficulty absorbing vitamin B12 from food absorb free vitamin B12 normally, their vitamin B12 deficiency tends to be less severe than that of individuals with pernicious anemia, who cannot absorb either food-bound or free vitamin B12

However, in guidelines published in 2012, the British Columbia Medical Association (Canadian Ministry of Health) recommended a dose of 1000 g/day for pernicious anemia or food-bound cobalamin malabsorption [34]