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Description

Eukaryotes often express several members of the HSP70 family, the main isoforms of which are found in all cellular compartments: Hsp72 (HSPA1A) and related HSP70 (Hsc70/HSPA8), in the cytosol and nucleus, BiP (Grp78/HSPA5) in the endoplasmic reticulum, and mtHSP70 (Grp75/mortalin/HSPA9) in mitochondria