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Lee et al, 2020

10.1016/j.ymthe.2019.04.021 [DOI] [PMC free article] [PubMed] [Google Scholar] 285.Tan J, Wang X, Cai S, He F, Zhang D, Li D, et al

Because the mid-portion of FAT anchors M-heat2, its movements relative to M-heat1 are facilitated by hinge rotations of M-heat, approaching the active conformation

Numerous studies have shown that the apoptotic pathway is involved in the pathogenesis of these diseases, and it is activated only as a last resort when there is no possibility of neurons recovery (Chi et al., 2018