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Despite this simple overall mechanism, increasing evidence indicates considerable molecular diversity in the manner in which AR executes transcription, leading to finetuning of and context-dependent output from the ARs transcriptional complex [30]

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The ongoing clinical trials of oral SERDs primarily focus on identifying subpopulations with potential benefits following CDK4/6 inhibitor failure, investigating the efficacy of SERDs in combination with CDK4/6 inhibitors as first-line therapy, and reducing mortality rates among high-risk populations during the adjuvant stage

Cancer 4 , 468484 (2023)