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Such studies could enhance the safe use of one of the most frequently taken drugs

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TABLE 1 Antituberculous medications known to be CYP450 enzyme system substrates or can impact its metabolic activity, possible effects of tobacco smoke compounds, and resulting potential interactions

ARE has been identified as a DNA-binding site for nuclear factor E2-related factor 2 (Nrf2), an antioxidant transcription factor that mediates ARE-driven upregulation of antioxidant genes and may act as a major regulator of the antioxidant cellular stress response [36]