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DEFB1 is an antimicrobial peptide which is highly expressed and active in the gut 88 , playing a potentially important role in maintaining gutmicrobiome homeostasis 89

J Neurosci (2007) 27:112938

Methyl groups added to cytosine residues, particularly in CpG-rich promoter regions, create binding sites for methyl-binding domain proteins that recruit additional chromatin-compacting machinery

However, there is reason to believe that a combination of the three could be synergistic due to the fact that they each regulate inflammation in a different way