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Beyond serving as a nitrogen source for nucleic acid and protein synthesis, ammonia accumulates in the TME through various metabolic pathways (91)

Detailed strain information is provided in Table S1

The vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a rare but severe adverse effect of post-COVID-19 vaccination, characterized by thrombocytopenia and major venous or arterial thrombosis

The evidence base requires appropriate clinical trials, with additional endpoints including clinical symptoms of patients and additional biochemical parameters beyond plasma B12 levels alone before these alternative routes can be recommended with confidence in clinical guidelines