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On the contrary, like in apoptosis, the cell membrane remains intact in eryptotic cells, so that heme, hemoglobin, and other potential erythrocyte-derived DAMPs are preserved from passive cell membrane destruction-associated liberation [78, 91]

This is why it tends to occur in older individuals, both male and female, and is more common in fair-skinned people

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Conclusion In sum, perturbation of Met metabolism may promote the damage process of hepatobiliary injury triggered by viral infections/toxins and/or niche abnormalities, with dysregulated inflammatory and immune responses of the liver, and contribute to the obliteration and eventual fibrosis and atresia of the bile ducts in the initiation/progression of BA