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Its analysis in IPF usually shows discrete neutrophilia with or without eosinophilia, and is use has been classically related with its ability to rule out other entities.2,3 The last international consensus indicated that BAL cellular analysis should not be performed systematically in all patients in the diagnostic procedure, although it may be appropriate for a minority.2 Nevertheless, in certain cases, BAL may be very helpful in the differential diagnosis with other entities such as chronic hypersensitivity pneumonitis or non-specific interstitial pneumonia

These DNA methylation alterations are linked not only to neurodevelopmental deficits but also to enduring impacts on cognitive abilities and behavior, highlighting their significance in the etiology and progression of these disorders

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