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Dysregulation of this metabolic checkpoint could lead to either excessive synaptic loss or the survival of damaged neurons, contributing to neurodevelopmental or neurodegenerative pathologies

Beyond motor symptoms, PD is associated with a variety of non-motor symptoms such as dysautonomia (for example, constipation, orthostatic hypotension) 3,4,5,13 , sleep disturbances (for example, rapid-eye-movement-onset sleep disorder) 1 , and the slowing and diminishment of voluntary behaviour (for example, bradykinesia, abulia, apathy, executive dysfunction) 14

Aburatani H

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