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Single-cell analyses revealed that these long-lived CD4 CAR-T cells possessed cytotoxic features alongside sustained functional activation and proliferation ( The inherent advantages of CAR-M for AID are primarily reflected in their high infiltration capacity into the ECM and their low interference with the immune microenvironment (103, 104)

Although pharmacological inhibitors like 3-MA have been used to infer involvement of autophagy ( in vivo efficacy remains limited

Data represent mean SD from three independent experiments

L-theanine is more focused on reducing stress and anxiety, whereas melatonin is focused on regulating the sleep-wake cycle