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Much of this increase is explained by changes in diagnostic practice, including: Broadening the definition of ASD to include higher-functioning children Increased accuracy in the diagnosis of ASD (particularly for children who previously may have been diagnosed with intellectual disability) Increased awareness of the disorder Earlier identification of young children However, we cannot rule out that there is a true increase in the risk for ASD

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However, the relationship between the number of OR and the cellular response is not linear

Proc Natl Acad Sci USA 1990;87:62586262 [DOI] [PMC free article] [PubMed] [Google Scholar] 73