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As summarized by Stier, Vos, and Kenley in 2013, the pre-specified primary endpoint for statistically significant weight change across the dose range and study duration was not met, while the compound's tolerability profile remained comparable to placebo

doi:10.1016/j.ntt.2006.05.003 Islam Z, Amuzie CJ, Harkema JR, Pestka JJ