acetaminophen glutathione toxicity Pathway (toxic doses), Pharmacokinetics Too much paracetamol = dangerous
Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem SUPER EASY MEMORY Too much Tylenol More NAPQI Less glutathione Liver dies NAC More glutathione Liver saved paracetamol overdose glutathione depletion Toxicology of Poisoning Pharm.D Aid The multiple mechanisms and modes Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology
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