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Protein-protein interaction network analysis for the identification of novel multi-target inhibitors and target miRNAs against Alzheimers disease

Further mechanistic studies showed that NNMTi increases intracellular NAD levels and activates the SIRT1 pathway by inhibiting NNMT, thereby suppressing the transcription of adipogenic genes and preventing the maturation of preadipocytes.This research provides a new perspective for understanding the molecular mechanism of adipocyte differentiation, confirms the key role of NNMTi in regulating adipogenesis, and lays a foundation for subsequent obesity intervention studies

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Table 1 The most commonly used exogenous testosterone preparations and their derivatives in strength-based doping (11, 13)