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17beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase

Other proposed mechanisms Changes across several key brain regions in response to UPF consumption may lead to reduced volumes of the mesocorticolimbic regions (30, 36), left ventral putamen, amygdala, and the dorsal frontal cortex (95)

In addition, NRF2 can also regulate the transcriptional expression of metabolites involved in intermediate metabolism, some of which play essential roles in the regeneration of NADPH, a key electron donor needed to reduce oxidative substrates [108]