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This process may be inhibited in the presence of FOXO4-DRI peptide, allowing p53 to bind with DNA and thereby help the cell cycle to continue to death

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Moreover, preconditioning MSC-EVs with traditional Chinese medicine (TCM) components, such as those from Salvia miltiorrhiza, upregulates hsa-miR-27a-5p_R-1 to modulate the signal transducer and activator of transcription 3 (STAT3)-SHANK2 (SH3 and multiple ankyrin repeat domains protein 2) axis, significantly improving the EVs anti-fibrotic and tissue-repair capabilities [194]