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Moreover, co-encapsulation of synbiotics and L-carnitine as a single microcapsule could be considered as a conceivable delivery system to enhance the stability and efficacy of synbiotics as well as to reduce the cost of the final product

2023;2(9):EVIDoa2200311

L-carnitine enhances fatty acid entry into the mitochondria, mitigating their toxic effects in the cytosol, and decreasing the inhibitory effect of acetyl-coenzyme A on the pyruvate dehydrogenase complex caused by intramitochondrial acetate.14 Studies that evaluate L-carnitine supplementation in critically ill patients suggest that it reduces inflammatory biomarkers compared to placebo.15,16 In addition, serum levels of carnitine and its esters in patients with sepsis and septic shock are strong predictors of patient mortality

Diagnosis, genetic characterization and clinical follow up of mitochondrial fatty acid oxidation disorders in the new era of expanded newborn screening: a single Centre experience