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Thereafter, the cells exhibit circadian cycles of gene expression for several consecutive days 11,12,13

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When the System Xc--GSH-GPX4 pathway is inhibited, intracellular GSH synthesis decreases and GPX4 activity is reduced, leading to the accumulation of lipid peroxides on the cell membrane

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Similar results were observed in off-road cyclists, where both short-term (6 d) and long-term (21 d) sodium phosphate supplementation (50 mg/kg) significantly increased VO 2max and maximal aerobic power, with no significant changes in 2,3-DPG levels (28)

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