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Introduction Sickle cell disease (SCD) is a genetic disorder that disproportionally affects people of African descent ( Intravascular hemolysis, a critical contributor to vaso-occlusive crises---the principal pathological manifestation of SCD---refers to the destruction of red blood cells (RBCs) within the blood vessels ( SCD pathophysiology In sickle cell disease, beta-globin, a component making up 50% of the Hb, has a genetic mutation