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While Igf1 ko animals were viable depending on genetic background and were non-fertile, the Igf1r ko animals died from respiratory failure but with an absence of apparent malformations

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Heres the whole thing in plain terms: What they did: built and validated a lab-grade method to accurately measure 5A1MQ in the blood, then dosed rats two ways intravenous (IV) and oral and tracked exactly how much showed up in circulation over time