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This study demonstrated that MgIG significantly inhibited the protein expression of COX-2 and 5-LOX, key enzymes in both metabolic pathways of arachidonic acid induced by LPS (Xie et al., 2015) (Figure 4)

Osteoblasts and osteoclasts functions are regulated by a system of neuropeptides from the central nervous system, which helps maintain the balance between bone formation and bone resorption (277)