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Autophagy is involved not only in clearing damaged mitochondria and protein aggregates but also in regulating mitochondrial mass, energy supply, and cell fate [109,110,111]

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10.1210/er.2002-0005 28 De MillianoI.Van HattumD.KetJ

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Much of the initial research about T cell exhaustion came out of HIV and hepatitis C research in the 90s

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