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Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice

Supporting a major role of oxidant stress in the thrombogenicity of moderate hyperhomocysteinemia, pretreatment by antioxidants prevents acute methionine load-induced endothelial and platelet dysfunctions in healthy subjects (Chambers et al, 1999

By binding to copper at the active site of tyrosinase and interfering with melanin synthesis intermediates, glutathione reduces overall melanin formation. As a powerful antioxidant, glutathione also reduces free radicalinduced oxidative stress, which is one of the triggers for increased tyrosinase activity and melanin production

URL: Noji M, Inoue K, Kimura N, Gouda A, Saito K (1998) Isoform-dependent differences in feedback regulation and subcellular localization of serine acetyltransferase involved in cysteine biosynthesis from Arabidopsis thaliana