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Oleanolic acid (OA), a natural pentacyclic triterpenoid, exerts anti-atherosclerotic effect in quail models and HUVECs where it was shown to inhibit oxLDL-induced LOX-1 and NADPH oxidase subunits expression while increasing the expression of Nrf2 and HO-1 ( -/- mice and it is suggested that Tan regulates cholesterol metabolism by reducing the expression of SR-A, while further enhancing ABCA1 and ABCG1 expression in human THP-1 cells via activation of ERK/Nrf2/HO-1 pathway (2) such as Tanshindiol C, epigallocatechin-3-gallate, and 4- O -methylhonokiol (MH) can regulate SR-A and CD36 receptors via Nrf2 activation and its downstream effects