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Healthcare providers should schedule follow-up within 2-4 weeks of starting tirzepatide to review glucose patterns, assess tolerability, and make necessary medication adjustments

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In addition, the analgesic effect of melatonin is mediated through activation of supraspinal sites, inhibition of spinal nociception, and modulation of various neurobiological systems, including GABAergic, opioid, and glutamatergic systems [65]