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Besides SOD and APX that directly scavenge ROS, this cycle also involves other enzymes such as MDHAR, DHAR, and GR, which act as antioxidant-regenerating enzymes that regenerate GSH and ASA from their oxidized forms (Mittler, 2002

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

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Another pathway through which polyphenols can increase insulin sensitivity is by activating AMP-activated protein kinase (AMPK), an essential regulator of energy metabolism (Xie et al., 2023)