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When you dont absorb enough B12 from your food to make red blood cells, your bodys oxygen capacity decreases, along with your endurance

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What happens if vitamin B12 is low

Additionally, incorporation with mucoadhesive polymers or targeting ligands further improves retention and brain targeting, while permeation enhancers may increase epithelial absorption, although safety considerations remain critical ( 4.4.4 Targeting synaptic dysfunction Synaptic dysfunction is widely recognized as one of the earliest and strongest correlates of cognitive decline in AD