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doi: 10.3389/fimmu.2025.1626082 Received 09 May 2025 Accepted 17 July 2025 Published 07 August 2025 Volume 16 - 2025 Edited by Seng-Lai Tan, TFC Therapeutics, United States Reviewed by Andrew L

M., Wilkie, T

We speculate that neuronal death in Alzheimers disease is essentially not degenerative but ischemic in nature, being caused synergically by the excessive intake of -6 PUFA-rich vegetable oils for oxidizing Hsp70.1 and long-standing brain ischemia due to age-dependent arteriosclerosis or A deposition in the capillary wall to facilitate -calpain activation